Allosteric DNA nanoswitches for controlled release of a molecular cargo triggered by biological inputs† †Electronic supplementary information (ESI) available: Supporting information. See DOI: 10.1039/c6sc03404g Click here for additional data file.

Nanoparticle “switch-on” by tetrazine triggering† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6cc05118a Click here for additional data file. Click here for additional data file. Click here for additional data file.

This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels-Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations. The power of these responsive nanoparticles is demonstrated through encapsulation of the anti-cancer agent d...

Electronic control of DNA-based nanoswitches and nanodevices† †Electronic supplementary information (ESI) available: Experimental procedures. See DOI: 10.1039/c5sc03694a Click here for additional data file.

Here we demonstrate that we can rationally and finely control the functionality of different DNA-based nanodevices and nanoswitches using electronic inputs. To demonstrate the versatility of our approach we have used here three different model DNA-based nanoswitches triggered by heavy metals and specific DNA sequences and a copper-responsive DNAzyme. To achieve electronic-induced control of the...

Allosteric DNA nanoswitches for controlled release of a molecular cargo triggered by biological inputs.

Here we demonstrate the rational design of a new class of DNA-based nanoswitches which are allosterically regulated by specific biological targets, antibodies and transcription factors, and are able to load and release a molecular cargo (i.e. doxorubicin) in a controlled fashion. In our first model system we rationally designed a stem-loop DNA-nanoswitch that adopts two mutually exclusive confo...

A counteranion triggered arylation strategy using diaryliodonium fluorides† †Electronic supplementary information (ESI) available: Experimental data for all new compounds and procedures. See DOI: 10.1039/c4sc02856b Click here for additional data file. Click here for additional data file.

Light-triggered chemical amplification to accelerate degradation and release from polymeric particles† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5cc06143a Click here for additional data file.